DEVELOPMENT OF A BIOPOLYMER COMPOSITION WITH ANTISEPTIC SUBSTANCES OF ORGANIC ORIGIN

Abstract

Purpose. Development of a biopolymer composition with antiseptic substances of organic origin and study of its physicochemical, technological, and antiseptic characteristics.

Methodology. Polyvinyl alcohol (PVA) and modified starch (Na-CMS) in various ratios were used to manufacture polymer films; etonium was used as the active pharmaceutical ingredient. Polymer films were obtained by pouring onto a horizontal surface (glass plates or metal plates). Rheological characteristics were studied on a rotational viscometer. The physical and mechanical properties of the samples were measured using a standard method on a tensile testing machine. To evaluate the structure and regenerative capacity of the systems after mechanical destruction, thixotropy studies were conducted. The compatibility of polymers in the compositions was evaluated by viscometry according to the Zellinger–Heydingsfeld criterion. The antimicrobial activity of the compositions was determined on test cultures of Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. Antifungal activity was evaluated against airborne fungi.

Findings. The article investigates the rheological characteristics of polymer solutions composed of modified starch (Na-CMS) and PVA. Results. The article investigates the rheological properties of polymer solutions comprising modified starch (Na-CMS) and PVA. It was found that all systems exhibit non-Newtonian behaviour; Na-CMS/PVA polymer films demonstrated the most stable characteristics and exhibited a high level of thixotropic viscosity recovery (up to 99%), ensuring uniform solution application during film formation by the pouring method without structural defects.

It was found that Na-CMS/PVA films with API demonstrate controlled water absorption and maintain structural integrity at relative humidity up to 80%, unlike starch-based films, which dissolve in a humid environment.

Mechanical tests have shown that films containing PVA exhibit higher strength and elasticity, especially at high humidity, enabling their use in creating transdermal and topical dosage forms.

The results of microbiological tests confirmed the pronounced activity of the developed polymer films against bacterial and fungal microflora.

Originality. For the first time, the composition and formation mechanisms of antiseptic polymer composite films with etonium have been substantiated, and their rheological and thermodynamic parameters have been determined, ensuring the stability of the systems and the necessary functional properties.

Practical value. The results obtained confirm the promise of using polymer compositions based on PVA and Na-CMS to create antiseptic dosage forms with controlled properties and can be used as specific carriers in the development of modern film-coated dosage forms.